ChromSword FAQ
Find answers to frequently asked questions about ChromSword. Learn how our software automates HPLC method development, simulation, and robustness testing.
Automated HPLC Method Development & Full Method Lifecycle
What is ChromSword?
ChromSword is software that automates HPLC method development from the first experiment to a robust final method. With full control over HPLC instrument it helps analytical chemists move away from trial-and-error and instead follow a structured, step-by-step process. The software explores chromatographic conditions, learns from each run, and gradually builds a reliable separation method. It […]
What problem does ChromSword solve?
Developing an HPLC method is often slow and unpredictable. Chemists may spend days or weeks testing conditions without knowing if they are moving in the right direction. ChromSword removes this uncertainty. It guides the process, reduces unnecessary experiments, and helps reach a working method much faster, especially when dealing with complex samples or impurities.
How does ChromSword work in practice?
ChromSword controls the HPLC system, runs experiments, evaluates the chromatograms, and decides what to try next. It does not just collect data—it actively learns from each run. Based on what it sees, it adjusts conditions such as gradient, solvent composition, temperature, or column choice to improve separation. This continues until a suitable method is reached.
Does ChromSword require an existing method to start?
No. ChromSword can start completely from scratch. This is important in real-world situations where no working method exists yet. The software performs initial screening and builds the method step by step. If a method already exists, ChromSword can also improve it.
How much time can ChromSword save?
In many cases, method development time can be reduced significantly. Instead of spending weeks testing conditions manually, laboratories often achieve results in days. Even without full automation, structured workflows typically reduce development time by 30–50%, with many projects exceeding 60%, depending on method complexity and user experience.
Can ChromSword handle difficult separations?
Yes. ChromSword is designed for challenging situations, including: It works even when the first chromatograms look unusable.
Method Development Workflow
What steps of method development does ChromSword cover?
ChromSword supports the entire HPLC method lifecycle, including: This is a key difference compared to many other tools, which focus only on a single part of the process.
What is meant by “full HPLC method lifecycle”?
The method lifecycle includes everything from the first idea of a separation to a method that can be used routinely in the lab. ChromSword is designed to support this complete process—not just modeling or statistical optimization, but the real experimental workflow from start to finish.
Can ChromSword improve existing methods?
Yes. If a method already exists but is not ideal, ChromSword can refine it by improving resolution, reducing run time, or increasing robustness.
Does ChromSword help with robustness?
Yes. Once a method is developed, ChromSword can explore how small changes in conditions affect the result. ChromSword designs the plan of experiments, execute runs, and prepare detailed robustness report including Design Space to define MODR. This helps ensure the method will perform reliably in daily use.
Comparison to Other Software
How is ChromSword different from simulation-based method development tools?
Simulation-based tools are designed to model chromatographic behavior based on a limited number of experimental runs. These approaches are helpful when: However, in practical situations: ChromSword takes a different approach. It performs real experimental screening and optimization, allowing it to: A simple way to look at it:
How is ChromSword different from statistical DoE-based approaches?
Statistical Design of Experiments (DoE) tools are used to study how selected parameters influence chromatographic results within a defined space. They are effective when: However: ChromSword does not depend on predefined experimental designs. It actively explores chromatographic conditions, learns from results, and adapts dynamically. This makes it particularly useful when:
How is ChromSword different from general modeling and prediction tools?
Modeling and prediction tools are useful for: These tools typically require: Their applicability becomes limited when: ChromSword focuses on experimental method development, allowing it to:
What is the main advantage of ChromSword compared to other approaches?
Most available solutions focus on individual parts of HPLC method development, such as: These tools are useful, but their applicability is often limited to specific stages of the workflow. ChromSword is designed differently. It supports the complete HPLC method lifecycle, including: Instead of assisting with separate tasks, ChromSword provides a continuous, connected workflow that leads […]
Comparison
This matrix provides a side-by-side technical comparison of traditional HPLC method development approaches—including simulation, statistical Design of Experiments (DoE), and modeling tools—against ChromSword. While traditional tools offer limited capabilities or require a pre-existing starting method, ChromSword delivers a fully automated, self-learning solution that natively handles unresolved peaks, complex/unknown samples, large molecule chemistry, and the full […]
Technology and AI
Does ChromSword use AI?
Yes. ChromSword uses advanced algorithms to analyze results and decide what to do next. The goal is not just prediction, but guided experimentation, learning from each run and improving the method step by step.
What does AI actually do in ChromSword?
It helps the system: This reduces unnecessary work and speeds up decision-making.
Laboratory Use
What types of labs use ChromSword?
ChromSword is used in:
Can ChromSword work with different HPLC systems?
Yes. It supports major instrument manufacturers and can be integrated into existing laboratory setups.
Is training required?
Basic training is recommended, but the system is designed to be practical and easy to use in everyday laboratory work.
Data and Security
Is my data secure?
Yes. All data remains within your laboratory or company environment.
Is data shared externally?
No. ChromSword does not send data outside your infrastructure.
Who owns the data?
You do. All results and experimental data remain fully under your control.
Getting Started
Can I request a demo?
Yes. A demo can be arranged either online or directly in your laboratory.
What does the demo include?
The demo shows how ChromSword performs in real HPLC method development scenarios. Online demoThe online demo demonstrates ChromSword using previously developed applications that are similar to your tasks and sample types. This gives a clear understanding of how the system works and what results can be expected. On-site demoThe on-site demo is performed in your […]
ChromSword is not just a modeling tool or a statistical package.
It is a one-of-a-kind system designed to support the entire HPLC method lifecycle—from the first experiment to a robust, ready-to-use analytical method.