ChromSword is software that automates HPLC method development from the first experiment to a robust final method. With full control over HPLC instrument it helps analytical chemists move away from trial-and-error and instead follow a structured, step-by-step process. The software explores chromatographic conditions, learns from each run, and gradually builds a reliable separation method. It […]

Developing an HPLC method is often slow and unpredictable. Chemists may spend days or weeks testing conditions without knowing if they are moving in the right direction. ChromSword removes this uncertainty. It guides the process, reduces unnecessary experiments, and helps reach a working method much faster, especially when dealing with complex samples or impurities.

ChromSword controls the HPLC system, runs experiments, evaluates the chromatograms, and decides what to try next. It does not just collect data—it actively learns from each run. Based on what it sees, it adjusts conditions such as gradient, solvent composition, temperature, or column choice to improve separation. This continues until a suitable method is reached.

No. ChromSword can start completely from scratch. This is important in real-world situations where no working method exists yet. The software performs initial screening and builds the method step by step. If a method already exists, ChromSword can also improve it.

In many cases, method development time can be reduced significantly. Instead of spending weeks testing conditions manually, laboratories often achieve results in days. Even without full automation, structured workflows typically reduce development time by 30–50%, with many projects exceeding 60%, depending on method complexity and user experience.