Within SIA “VMKC” competence centre, ChromSword realizes a research project on “Chromatographic behavioural research on widely available active pharmaceutical ingredients in the market”<\/p>\n
The project aims to develop mathematical models for widely used active pharmaceutical substances that will be included in the ChromSword software package and will allow analysts to develop liquid chromatography methods for research-related substances more quickly.<\/p>\n
Currently work is ongoing to complete 3rd part of the project. Tests are being executed to complete
\nlast set of 10 API samples that should be finished by the end of the year 2020.<\/p>\n
As part of the project, the development of mathematical models and their testing of API behaviour under highly efficient liquid chromatography will continue. The forecasting accuracy of the designed models is performed compared to real experimental data.<\/p>\n
The project timeline is from 01.05.2019. to 30.09.2021.<\/p>\n
Updated 30.09.2021.<\/p>\n
***<\/p>\n
SIA \u201cVMKC\u201d Kompetences centra ietvaros ChromSword realiz\u0113jis p\u0113tniec\u012bbas projektu par \u201cHromotogr\u0101fisk\u0101s uzved\u012bbas p\u0113t\u012bjums tirg\u016b pla\u0161i pielietojam\u0101m akt\u012bv\u0101m farmaceitisk\u0101m viel\u0101m\u201d<\/p>\n
Projekta m\u0113r\u0137is bija izstr\u0101d\u0101t matem\u0101tiskus mode\u013cus tirg\u016b pla\u0161i izmantojam\u0101m akt\u012bv\u0101m farmaceitisk\u0101m viel\u0101m, kas tiks iek\u013cauti ChromSword programnodro\u0161in\u0101juma pak\u0113t\u0113 un dos iesp\u0113ju anal\u012bti\u0137iem daudz \u0101tr\u0101k izstr\u0101d\u0101t \u0161\u0137idruma hromotogr\u0101fijas metodes p\u0113t\u012bjumiem, kas saist\u012bti ar p\u0113t\u0101maj\u0101m viel\u0101m.<\/p>\n
Project gait\u0101 ir veikti p\u0113t\u012bjumi ar vair\u0101k k\u0101 30 da\u017e\u0101diem API paraugiem deatilz\u0113ti izanaliz\u0113jot to uzved\u012bbu apgriezt\u0101s f\u0101zes \u0161\u0137idruma hromotogr\u0101fijas apst\u0101k\u013cos. Balstoties uz ieg\u016btajiem datiem tika izstr\u0101d\u0101ti un v\u0113l\u0101k test\u0113ti matem\u0101tieskie mode\u013ci API uzved\u012bbas prognoz\u0113\u0161anai.<\/p>\n
Projekta gait\u0101 piln\u012bb\u0101 tiki saskniegti uzst\u0101d\u012btie m\u0113r\u0137i, tas ir veikti p\u0113t\u012bjumi un izstr\u0101d\u0101ti prec\u012bzi API uzvad\u012bbas mode\u013ci, kas eksperiment\u0101l\u0101s izstr\u0101des rezult\u0101t\u0101 tika p\u0101rbaud\u012bti un t\u0101d\u0101 veid\u0101 apstiprin\u0101ta to precizit\u0101te.<\/p>\n
\u0145emot v\u0113r\u0101 visus iepriek\u0161\u0113jos faktus, tad balstoties uz p\u0113t\u012bjum\u0101 ieg\u016btajiem datiem un izstr\u0101d\u0101tajiem mode\u013ciem ChromSword pl\u0101no papla\u0161in\u0101t eso\u0161o produktus ar jaunu industrijai nepiecie\u0161amu funkcionalit\u0101ti, kas saist\u012bta ar API uzved\u012bbas prognoz\u0113\u0161anu.<\/p>\n
Pojekta realiz\u0101cijas termi\u0146\u0161 no 01.05.2019. l\u012bdz 30.09.2021.<\/p>\n
Atjaunots 30.09.2021.<\/p>\n
Currently completed stages (Updated on September 30, 2021):<\/p>\n
In the first stage of the research project first 10 API samples were tested. During the tests were studied retention behavior of API’s in HPLC.
\nIn the second stage of the project, chromatographic tests with API samples and their behavioural retention under HPLC conditions were studied. 10 more API samples were tested.
\nChromSword is finished work with the 2nd stage of research to study the effects of stationary phases on the behaviour of AFV substances within HPLC configurations and started 3rd stage to research the next batch of active pharmaceutical samples.
\nTests were completed for 3rd stage of project. 12 new active samples were tested and additional tests were made for 1st and 2nd stage samples.
\nCompleted experimental research, currently in the process of mathematical analysis and chromatographic model development.
\nThe development of mathematical models and their testing of API behaviour under highly efficient liquid chromatography will continue. The forecasting accuracy of the designed models is performed compared to real experimental data.
\n***<\/p>\n
Projekta ietvaros uz \u0161o br\u012bdi ir veiktas sekojo\u0161as aktivit\u0101tes (Atjaunots 30.septembr\u012b 2021):<\/p>\n
Projekta pirmaj\u0101 etap\u0101 veikti hromotogr\u0101fiskie testi ar pirmajiem 10 akt\u012bvo farmaceitisko vielu (turpm\u0101k tekst\u0101 API) paraugiem izpl\u0113tot to uzved\u012bbas \u012bpatn\u012bbas HPLC apst\u0101k\u013cos.
\nProjekta otraj\u0101 etap\u0101 tika turpin\u0101ti hromotogr\u0101fiskie testi ar API paraugiem izp\u0113tot to uzved\u012bbas \u012bpatn\u012bbas HPLC apst\u0101k\u013cos. Otraj\u0101 etap\u0101 tika izanaliz\u0113ti v\u0113l 10 API paraugi.
\nChromSword pabeidza p\u0113t\u012bjumus projekta 2.etapa ietvaros un uzs\u0101ka projekta 3.etapu p\u0113tot n\u0101kamos Akt\u012bvo Farmac\u0113tisko Vielu paraugus.
\nTika veikti testi ar projekta 3.etap\u0101 paredz\u0113tiem 12 jauniem Akt\u012bvo Farmac\u0113tisko vielu paraugiem, k\u0101 ar\u012b tika viekti papildus testi ar 1. un 2. k\u0101rt\u0101 iek\u013cautiem paraugiem.
\nPabeigti visi eksperiment\u0101lie p\u0113t\u012bjumi un uzs\u0101kta datu matem\u0101tiska apstr\u0101de un paraugu hromotogr\u0101fisk\u0101s uzvedibas mode\u013cu izstr\u0101de.
\nMatem\u0101tisko mode\u013cu izstr\u0101de un to test\u0113\u0161ana par API uzved\u012bbu augsti efekt\u012bvas \u0161\u0137idruma hromatogr\u0101fijas apst\u0101k\u013cos. Tiek veikta izstr\u0101d\u0101to mode\u013cu prognoz\u0113\u0161anas precizit\u0101te sal\u012bdzinot ar re\u0101liem eksperiment\u0101liem datiem.<\/p>\n","protected":false},"featured_media":87,"template":"","class_list":["post-372","project","type-project","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/chromsword.com\/it\/wp-json\/wp\/v2\/project\/372","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chromsword.com\/it\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/chromsword.com\/it\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":0,"href":"https:\/\/chromsword.com\/it\/wp-json\/wp\/v2\/project\/372\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chromsword.com\/it\/wp-json\/wp\/v2\/media\/87"}],"wp:attachment":[{"href":"https:\/\/chromsword.com\/it\/wp-json\/wp\/v2\/media?parent=372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}